Cellular Therapy for Heart Failure

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Cellular Therapy for Heart Failure

The pathogenesis of cardiomyopathy and heart failure (HF) is underpinned by complex changes at subcellular, cellular and extracellular levels in the ventricular myocardium. For all of the gains that conventional treatments for HF have brought to mortality and morbidity, they do not adequately address the loss of cardiomyocyte numbers in the remodeling ventricle. Originally conceived to address ...

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Correspondence: A. Terzic, MD, PhD, Mayo Clinic, 200, First Street SW, Rochester, MN 55905, United States E-mail: [email protected] The pandemic of ischemic heart disease is increasingly recognized as a leading cause of global morbidity. While modern treatment modalities for acute myocardial infarction have reduced early mortality, they have concurrently precipitated a higher incidence of c...

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Heart failure is an important public medical problem in the developed countries. Although there are numerous and fascinating medicines given by physicians for the treatment of heart failure, the general 5 year survival rate for advanced heart failure is only about 50%. There are still many theoretical and practical problems to overcome before the application of gene therapy to cardiovascular di...

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Cardiac energetic impairment is a feature of systolic heart failure irrespective of the underlying etiology, and the magnitude of this impairment is predictive of subsequent mortality. It is also a feature of other forms of heart muscle diseases including hypertrophic cardiomyopathy and heart failure with normal ejection fraction. While the adult heart normally uses predominantly free fatty aci...

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ژورنال

عنوان ژورنال: Current Cardiology Reviews

سال: 2016

ISSN: 1573-403X

DOI: 10.2174/1573403x12666160606121858